Detailed Information on Neurosarcoidosis

                                                                                         

Neurosarcoidosis refers to the neurological manifestations of sarcoidosis. Sarcoidosis is a progressive multisystem disease that commonly influences young adults. Sarcoidosis is a chronic disorder that affects many body systems. Sarcoidosis affects many body systems. Over 90% of cases involve the lungs and may also involve any other area of the body. Sarcoidosis is characterized by an abnormal immune system response that produces deposits of white blood cells and abnormal tissue cells in the affected organ. A small percentage of cases will involve some portion of the nervous system (neurosarcoidosis).

Neurosarcoidosis may simulate any part of the nervous system. Sudden, transient facial palsy (facial weakness) is common with involvement of cranial nerve VII. The condition can also affect a part of the brain called the hypothalamus, which is involved in regulating several body functions such as temperature, sleep, and stress responses. Sarcoidosis occurs in highly variable groups. Neurosarcoidosis is more common in Africans, including those living in the West Indies, than any other people. It is very uncommon in Chinese, Southeast Asians, Inuits, Canadian Indians, and New Zealand Maoris. Slightly more common in women than men.

In the U.S. it is more common in blacks, while in Europe it is more common in whites. The disorder is faintly more common in people aged 25-50, particularly women, but can arise at any age and to either gender. It is very rare in children. When it does affect children, sarcoidosis usually involves the lungs. Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis. Visual problems may also be the result of papilledema (swelling of the optic disc) due to obstruction by granulomas of the normal cerebrospinal fluid (CSF) circulation.

It can effect headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior. Peripheral neuropathy has been reported. Neurosarcoidosis can show in an acute, explosive fashion or start as a sluggish chronic illness. Treatment is indicated if symptoms are severe or progressive. Corticosteroids or immunosuppressive drugs may relieve symptoms in selected patients. Immunosuppressive drugs such as methotrexate, azathioprine, cyclosporin, and cyclophosphamide, have benefited some individuals. Risperidone and other antipsychotic drugs have been used for the treatment of neurosarcoidosis.

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Juliet Cohen writes articles for beauty blog. She also writes articles for new hairstyles and hairstyles blog.

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